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Altogether, our details supply evidence with the likely of mixing CX-5461 and PARPi for increasing the cure of HR-deficient HGSOC. We demonstrate that CX-5461 improves the artificial lethal conversation of PARPi with HRD and Obviously clearly show that CX-5461 has a distinct mechanism of action to PARPi. Importantly, we characterized BRCA-mutated a

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